STEROIDAL SAPOGENINS

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Preliminary pharmacobiological study of new steroidal sapogenins.

The chemotherapeutic study of a limited series of steroidal sapogenins from several endemic species of the flora of the Canary Islands is presented here. On the whole, they possess a very weak antibacterial activity, a slight antifungal effect and one of them, vespertilin, displays interesting cytostatic activity (ID50 = 5 micrograms/ml). A pharmacodynamic screening carried out on this product ...

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Effect of steroidal sapogenins on ruminal fermentation and on production of lactating dairy cows.

Supplementation of dairy rations with steroidal sapogenins was evaluated in an in vitro, an in situ, and a production trial. Sixteen in vitro semicontinuous rumen cultures were supplied a 55:45 concentrate to roughage substrate with Sarsaponin concentrations of 0, 33, 55, and 77 ppm of air-dry feed for 22 d. Supplementation decreased protozoa numbers and increased bacterial numbers and acid det...

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De novo Transcriptome Assembly and the Putative Biosynthetic Pathway of Steroidal Sapogenins of Dioscorea composita

The plant Dioscorea composita has important applications in the medical and energy industries, and can be used for the extraction of steroidal sapogenins (important raw materials for the synthesis of steroidal drugs) and bioethanol production. However, little is known at the genetic level about how sapogenins are biosynthesized in this plant. Using Illumina deep sequencing, 62,341 unigenes were...

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Saponins and Sapogenins

The seeds of Luffa aegyptica Mill, locally known as "ghia torai" (family Cucurbitaceae), have earlier been studied for the saponin and sapogenin contents and found to contain a mixture of colourless saponins which on hydrolysis yields two acid and a neutral sapogenin. The acetates of the two acid genins melted at 266-268" and 176-181" while the neutral genin acetate melted at 262-264O.l The aci...

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Saponins and Sapogenins from Brachiaria decumbens Stapf

Quatro saponinas esteroidais e três sapogeninas foram identificadas das partes aéreas de Brachiaria decumbens. As estruturas desses compostos foram estabelecidas através de métodos químicos e espectroscópicos (RMN de H e C, HMBC, HMQC) como 3 -metóxi-lanost-9(11)-eno (1), diosgenina (2a), iamogenina (2b), 3-O-D-glicopiranosil-24(S)-etil-22E-deidrocolesterol (3a), 3O-D-glicopiranosil-24(R)-etil-...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1952

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)55508-3